Permax / Dostinex
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What is Dostinex?
The presrption drugs Permax and Dostinex are both drugs from a class of medications that are called ergot-derived dopamine receptor agonists. These drugs are used in the treatment by doctors for Parkinson's, Restless Leg Syndrome, and in some cases migraine headaches. Other ergot-derived dopamine receptor drugs include the now banned diet combo drug Fen-Phen. Fen-Phen if you recall was pulled in the 1990's for it cause in heart valve disease. Permax (pergolide) has been found in studies to make a patient five to seven times more likely to have leaky heart valves than those patients who use other drug therapies for Parkinson's. Dostinex (cabergoline) has only been approved for sale in the United States to treat hyperprolactinemia, a condition in which excessive amounts of the hormone prolactin enter the bloodstream due to benign tumors of the pituitary gland. It has been shown in studies that Permax and Dostinex both can interact with a receptor in the heart valve, causing the valve to overgrow and become floppy and leaky. Of the two, only Permax currently has a black box warning addressing the increased risk of heart valve problems in patients.
In a study published in the January of 2007 in the New England Journal of Medicine, it concluded that patients taking Permax or Dostinex, two drugs commonly used to treat Parkinson's, Restless Leg Syndrome, and Migraine Headaches, are four to seven times more likely to suffer from heart valve damage than patients on alternative drug therapies. Patients who take Permax or Dostinex are four to seven times more likely to suffer damage to their heart valves than patients who did not take either of these medications. The January 4, 2007 issue of The New England Journal of Medicine (NEJM) contains articles about two case studies that provide some of the strongest evidence that treatment with the Parkinson's disease drugs Permax (pergolide) and Dostinex (cabergoline) can cause cardiac-valve dysfunction.
Our Law Firm believes that individuals who suffered a serious injury or death due to the drugs Permax or Dostinex have legal rights that should be protected. We believe the manufactures should be held accountable for these injuries. If you or a family member have been diagnosed with a Cardiac Valve Regurgitation and have taken the drug PERMAX or DOSTINEX - Call our Law Firm day or night, you may have a claim against the makers of the drugs. The call to our Law Firm is free and without obligation. Call us toll free at 1-800-862-1260.
PERMAX: Parkinson's Drug PERMAX Increases the Risk of Cardiac Valve Regurgitation, if used long-term.
If you or a family member or friend is using the drug Permax, please read the following. If you have been diagnosed with a Cardiac Valve Regurgitation, call our Law Firm, you may have a claim against the makers of the drug Permax.
A new study was published and released in the March 2007 giving additional warnings on the drug Permax. In the March 2007 issue of the medical news journal Archives of Neurology a new study provides further support to the theory that the long-term use of Permax (pergolide) for Parkinson's disease increases the risk of valvulopathy, primarily cardiac valve regurgitation. By comparison, the same study found that Mirapex (pramipexole) and Requip (ropinirole), two non-ergot-derived dopamine agonists used for the treatment of Parkinsons, were not associated with any increased risk of heart valve damage. If you or a family member are using this drug you should consult with your doctor, as soon as possible. If you or a family member have been diagnosed with a Cardiac Valve Regurgitation - call our Law Firm day or night, you may have a claim against the makers of the drug.
The newly released report is called "Cardiac Valve Regurgitation With Pergolide Compared With Nonergot Agonists in Parkinson Disease". According to the report, one of the objectives of this case-control study was to determine if cardiac valve regurgitation occurs more commonly in patients with Parkinson disease (PD) treated with Permax (pergolide) than in those treated with Mirapex and Requip, the nonergot agonists, at a comparable dose. The study found the occurrence of cardiac valve regurgitation in 36 Permax users and 36 matched users of Mirapex or Requip. In the Permax group, the average regurgitation scores was much higher than the other two drugs. Thus concluding that your risk is much higher. Specifically the report showed Permax users in the study had regurgitation issues 0.83 for the aortic valve, 1.42 for the mitral valve, and 1.43 for the tricuspid valve, whereas in the Mirapex / Requip group the average regurgitation scores were 0.19 for aortic valve, 0.39 for mitral valve, and 0.19 for tricuspid valve.
Dr. Richard B. Dewey, from the University of Texas Southwestern Medical Center in Dallas, made the following observations:
Based on these findings and the earlier findings on this matter, "we continue to advise patients who are taking pergolide to stop taking the drug if possible and, if not, to undergo yearly echocardiography looking for valve regurgitation," the authors state. "Our practice of recommending non-ergot dopamine agonists as first-line therapy for patients needing a dopamine agonist appears to be relatively safe from the standpoint of cardiac valve function."
If you or a family member have been diagnosed with a Cardiac Valve Regurgitation have taken the drug PERMAX- call our Law Firm day or night, you may have a claim against the makers of the drug. The call to our Law Firm is free and without obligation. Call us toll free at 1-800-862-1260.
Permax and Dostinex: Civil Liability
If you or a loved one has experienced serious side effects from the use of prescription drugs Permax or Dostinex, or if a loved one has died while using the Permax or Dostinex, you may have a claim for legal compensation. Legal compensation claims involving injuries and/or death caused by the use of Permax or Dostinex can be made by the filing a lawsuit in court against the makers of the drug. However, each and every state has a statutes of limitations that determines the time period allowed to file a claim or a lawsuit. The applicable statute of limitation, or the deadline to file a claims, varies from each state and the personal injury statute of limitation deadline can be different from the wrongful death statute of limitation deadline within the same state. For example, in some states a personal injury claim must be filed within 3 years from the date a Permax or Dostinex injury is diagnosed, while a wrongful death claim must be filed within 2 years from the date of a death. In some states, the statutes of limitations may be as short as 1 year from the date of diagnosis or death.
In Texas only two years to file a lawsuit are give. Some exceptions can exist if the cause of the death was unknown. The best advise is to pick up the phone now and call our Law Firm day or night. We will get you the answers you need. Our Law Firm believes that individuals who suffered a serious injury or death due to the drugs Permax or Dostinex have legal rights that should be protected. We believe the manufactures should be held accountable for these injuries. If you or a family member have been diagnosed with a Cardiac Valve Regurgitation and have taken the drug PERMAX or DOSTINEX - Call our Law Firm day or night, you may have a claim against the makers of the drugs. The call to our Law Firm is free and without obligation. Call us toll free at 1-800-862-1260.
A Dear Healthcare Professional Letter written by Eli Lilly to Precribing Doctors:
MedWatch - Permax (pergolide) Dear Healthcare Professional letter written by Eli Lilly in July 2003
CALL OUR LAW FIRM WE CAN HELP:
If you or a loved one has experienced serious side effects from the use of Permax or Dostinex, or a person has died due to an adverse reaction while using the Permax or Dostinex, you may have a claim for legal compensation. The applicable statute of limitation, or deadline to file claims, varies from state to state, and the personal injury statute of limitation deadline can be different from the wrongful death statute of limitation deadline within the same state. In Texas only two years to file a lawsuit are give. Some exceptions can exist if the cause of the death was unknown. The best advise is to pick up the phone now and call our Law Firm day or night. We will get you the answers you need. Our Law Firm believes that individuals who suffered a serious injury or death due to the drugs Permax or Dostinex have legal rights that should be protected. We believe the manufactures should be held accountable for these injuries. If you or a family member have been diagnosed with a Cardiac Valve Regurgitation and have taken the drug PERMAX or DOSTINEX - Call our Law Firm day or night, you may have a claim against the makers of the drugs. The call to our Law Firm is free and without obligation. Call us toll free at 1-800-862-1260.
- US FDA advises that you should not stop taking any prescription medication before talking to your doctor.
- Reports of serious drug side effects should be made to the US FDA MedWatch Program.
- The prescription drug names are registered trademarks of the respective drug companies.
- Our Law Firm is not affiliated with any of the drug companies, nor US FDA.
TRADEMARK NOTICE: Permax and Dostinex are trademarks of Eli Lilly & Co and Pfizer, Inc. accordingly.
The Carabin & Shaw Law Firm, its' lawyers and this website is in no way affiliated with Eli Lilly & Co and Pfizer, Inc. The use of this mark is solely for informational and product identification purposes.
