Nephrogenic Systemic Fibrosis



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Nephrogenic Systemic Fibrosis

What Is Nephrogenic Fibrosing Dermopathy/Nephrogenic Systemic Fibrosis?
Nephrogenic systemic fibrosis (NSF) is a rare disorder that is predominantly characterized by a clinicopathologically distinct symmetric dermopathy and debilitating joint contractures. The condition affects patients with renal insufficiency and appears to show improvement in some with prompt restoration of renal function.

Hundreds of cases of NSF have been reported in the nephrogenic fibrosing dermopathy/NSF registry that is currently maintained at the Yale University. Recent reports suggest a etiologic link between systemic administration of gadolinium-containing magnetic resonance imaging contrast agents in patients with renal insufficiency and the development of NSF.

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